Binary Outcomes Are Not Better than Continuous Variables in Randomized Controlled Trials
نویسندگان
چکیده
منابع مشابه
Blindness in Randomized Controlled Trials
In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
متن کاملIs using multiple imputation better than complete case analysis for estimating a prevalence (risk) difference in randomized controlled trials when binary outcome observations are missing?
BACKGROUND Missing outcomes can seriously impair the ability to make correct inferences from randomized controlled trials (RCTs). Complete case (CC) analysis is commonly used, but it reduces sample size and is perceived to lead to reduced statistical efficiency of estimates while increasing the potential for bias. As multiple imputation (MI) methods preserve sample size, they are generally view...
متن کاملPatient-reported outcomes better discriminate active treatment from placebo in randomized controlled trials in rheumatoid arthritis.
BACKGROUND Recent randomized controlled trials (RCTs) in rheumatoid arthritis (RA) have used patient- and physician-reported outcomes, ESR and/or CRP as components of ACR response criteria to assess efficacy. OBJECTIVES Mean changes from baseline in patient- and physician-reported outcome measures, ESR and CRP were compared in two RCTs in patients with active RA. Comparisons between active an...
متن کاملThe transitive property across randomized controlled trials: if B is better than A, and C is better than B, will C be better than A?
In everyday practice, clinicians are faced with questions on the comparative benefits and risks of the various health interventions available to treat patients. When performed well and reported completely, randomized controlled trials (and systematic reviews of such trials) are generally considered to be the most scientifically rigorous approach to determine whether a cause-effect relationship ...
متن کاملblindness in randomized controlled trials
in combination with randomization, blinding or masking is an important factor in randomized controlled trials (rcts), particularly in trials that assess therapeutic effects. here an attempt is made to explain blindness and why it is important. in clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2014
ISSN: 0022-202X
DOI: 10.1038/jid.2013.256